SKF83959|cas:80751-85-5|西域试剂

SKF83959

产品编号：Bellancom-130344| CAS NO：80751-85-5| 分子式：C₁₈H₂₀ClNO₂| 分子量：317.81

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货号	价格	库存与货期
Bellancom-130344	￥1900.00	杭州北京（现货）
Bellancom-130344	￥3000.00	杭州北京（现货）
Bellancom-130344	￥6000.00	杭州北京（现货）

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SKF83959

产品介绍

SKF83959 是一种有效的选择性多巴胺 D₁-like 受体部分激动剂。SKF83959 K_i 对大鼠 D₁，D₅，D₂和D₃ 的值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 是一种有效的 sigma (σ)-1 受体变构调节剂。SKF83959 属于 benzazepine 家族，对认知功能障碍有改善作用。SKF83959 可用于研究阿尔茨海默病和抑郁症。

生物活性

SKF83959 is a potent and selective dopamine D₁-like receptor partial agonist. SKF83959 K_i values for rat D₁, D₅, D₂ and D₃ receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression^[4].

体外研究

SKF83959 (10~250 μM) stimulates PIP2 hydrolysis in membranes. SKF83959 (0.1~10 μM; PC12 cell) changes the EC₅₀ value of SKF81297 from 0.5 nM in control tissue to 31.6 nM, 251.2 nM and 631.0 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SKF83959 (0.5 and 1 mg/kg; i.p.; 1 hour) reverses the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.
SKF83959 (1 mg/kg; i.p.; 30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade.
SKF83959 has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	0.5 and 1 mg/kg
Administration:	I.p.; 1 hour
Result:	Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	1 mg/kg
Administration:	I.p.; 30 minutes
Result:	The memory enhancing effects were prevented by BDNF system blockade.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	0.5 and 1 mg/kg
Administration:	I.p.; 1 hour
Result:	Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	1 mg/kg
Administration:	I.p.; 30 minutes
Result:	The memory enhancing effects were prevented by BDNF system blockade.