Adenosine A1 receptor activator T62,98.0%

产品编号:Bellancom-106199| CAS NO:40312-34-3| 分子式:C15H14ClNOS| 分子量:291.80

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Bellancom-106199
3900.00 杭州 北京(现货)

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Adenosine A1 receptor activator T62

产品介绍 Adenosine A1 receptor activator T62 是腺苷 A1 受体 (adenosine A1 receptor) 的变构增强剂。Adenosine A1 receptor activator T62 在急性疼痛的动物模型中产生抗伤害感受,并在炎性和神经损伤性疼痛的模型中降低超敏反应。
生物活性

Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.

体外研究
体内研究

Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SpragueDawley rats (250 g) after paw incision surgery
Dosage: 0.3 μg, 0.5 μg, 1 μg, and 3 μg
Administration: Intrathecal administration
Result: Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
体内研究

Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SpragueDawley rats (250 g) after paw incision surgery
Dosage: 0.3 μg, 0.5 μg, 1 μg, and 3 μg
Administration: Intrathecal administration
Result: Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
性状Solid
溶解性数据
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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