SIB-1553A|cas:191611-89-9|西域试剂

SIB-1553A,99.09%

产品编号：Bellancom-107676| CAS NO：191611-89-9| 分子式：C₁₃H₂₀ClNOS| 分子量：273.82

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-107676		￥5700.00	杭州北京（现货）
Bellancom-107676		￥9600.00	杭州北京（现货）

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SIB-1553A

产品介绍

SIB-1553A 是一种口服生物有效的烟碱乙酰胆碱受体 (nAChRs) 激动剂，对含有 nAChRs 的 β4 亚单位具有选择性。SIB-1553A 也是一种选择性配体神经元 nAChR 配体。SIB-1553A 是一种认知增强剂，对阿尔茨海默病和其他认知障碍的症状研究具有潜在的研究潜力。

生物活性

SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.

体外研究

SIB-1553A displaces the binding of ^[H]nicotine (NIC) to the rat brain nAChRs with an IC₅₀ value of 110 nM.
In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (200-250 g)
Dosage:	1, 2, 4, 10, 20 and 40 mg/kg
Administration:	s.c.
Result:	Induced hippocampal ACh release.

体内研究

SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (200-250 g)
Dosage:	1, 2, 4, 10, 20 and 40 mg/kg
Administration:	s.c.
Result:	Induced hippocampal ACh release.

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 27.38 mg/mL (99.99 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6520 mL	18.2602 mL	36.5203 mL
5 mM	0.7304 mL	3.6520 mL	7.3041 mL
10 mM	0.3652 mL	1.8260 mL	3.6520 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶