Virodhamine|cas:287937-12-6|西域试剂

Virodhamine,98.0%

产品编号：Bellancom-116418| CAS NO：287937-12-6| 分子式：C₂₂H₃₇NO₂| 分子量：347.53

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货号	价格	库存与货期
Bellancom-116418	￥850.00	杭州北京（现货）
Bellancom-116418	￥1450.00	杭州北京（现货）
Bellancom-116418	￥3000.00	杭州北京（现货）
Bellancom-116418	￥4850.00	杭州北京（现货）
Bellancom-116418	￥7800.00	杭州北京（现货）

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Virodhamine

产品介绍

Virodhamine 是一种内源性大麻素，它通过激活大麻素 (CB) 受体调节神经传递。Virodhamine 是 CB1 受体的拮抗剂和 CB2 受体的激动剂。Virodhamine 通过触发 MAPK 信号和 ROS 的产生诱导巨核细胞分化。 Virodhamine 可用于治疗各种神经疾病，如阿尔茨海默病和帕金森。

生物活性

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.

体外研究

Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus.
Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1.
Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control.
Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR

Cell Line:	Megakaryocyte cell line
Concentration:	10, 20 and 40 μM
Incubation Time:	72 h
Result:	Dose‐dependently enhanced the expression level of megakaryocytic marker CD61 and the expression of TRPV1 mRNA.

体内研究
(In Vivo)

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety
Dosage:	1, 5 and 10 mg/kg
Administration:	Intraperitoneal injection; 1-10 mg/kg; once
Result:	Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.

体内研究

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety
Dosage:	1, 5 and 10 mg/kg
Administration:	Intraperitoneal injection; 1-10 mg/kg; once
Result:	Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.

体内研究

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety
Dosage:	1, 5 and 10 mg/kg
Administration:	Intraperitoneal injection; 1-10 mg/kg; once
Result:	Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.

性状

Viscous liquid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (287.74 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8774 mL	14.3872 mL	28.7745 mL
5 mM	0.5755 mL	2.8774 mL	5.7549 mL
10 mM	0.2877 mL	1.4387 mL	2.8774 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式