Cyclo(his-pro) Cyclo(histidyl-proline; Histidylproline diketopiperazine)|cas:53109-32-3|西域试剂

Cyclo(his-pro) Cyclo(histidyl-proline; Histidylproline diketopiperazine)

产品编号：Bellancom-101402| CAS NO：53109-32-3| 分子式：C₁₁H₁₄N₄O₂| 分子量：234.25

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-101402	￥500.00	杭州北京（现货）
Bellancom-101402	￥900.00	杭州北京（现货）
Bellancom-101402	￥1500.00	杭州北京（现货）
Bellancom-101402	￥2900.00	杭州北京（现货）
Bellancom-101402	￥5400.00	杭州北京（现货）

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Cyclo(his-pro) Cyclo(histidyl-proline; Histidylproline diketopiperazine)

产品介绍

Cyclo(his-pro) (Cyclo(histidyl-proline)) 是一种具有口服活性的，结构上与促甲状腺激素释放激素相关的环状二肽。Cyclo(his-pro) 可以抑制 NF-κB 核积累。Cyclo(his-pro) 可以穿越脑血屏障并影响多种炎症和应激反应。

生物活性

Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

体外研究

cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors.
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release.
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	PC12 cells
Concentration:	50 μM
Incubation Time:	1, 2, 4, 8, 24, 48 hours
Result:	Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation.

体内研究
(In Vivo)

Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect.
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sixty two/three month-old male C57BL/6 mice (25-30 g)
Dosage:	1.8 mg/ear
Administration:	Topical application on the right ear; 30 min prior to TPA
Result:	Reduced TPA-induced ear oedema.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sixty two/three month-old male C57BL/6 mice (25-30 g)
Dosage:	1.8 mg/ear
Administration:	Topical application on the right ear; 30 min prior to TPA
Result:	Reduced TPA-induced ear oedema.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sixty two/three month-old male C57BL/6 mice (25-30 g)
Dosage:	1.8 mg/ear
Administration:	Topical application on the right ear; 30 min prior to TPA
Result:	Reduced TPA-induced ear oedema.

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 30 mg/mL (128.07 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.2689 mL	21.3447 mL	42.6894 mL
5 mM	0.8538 mL	4.2689 mL	8.5379 mL
10 mM	0.4269 mL	2.1345 mL	4.2689 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式