Apovincaminic acid hydrochloride salt|cas:72296-47-0|西域试剂

Apovincaminic acid hydrochloride salt,98.0%

产品编号：Bellancom-133813A| CAS NO：72296-47-0| 分子式：C₂₀H₂₃ClN₂O₂| 分子量：358.86

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-133813A		￥3000.00	杭州北京（现货）

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Apovincaminic acid hydrochloride salt

产品介绍

Apovincaminic acid hydrochloride salt 是 Vinpocetine (VP) 的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminic acid hydrochloride salt 具有神经保护作用。

生物活性

Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action.

体外研究

体内研究

Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation.
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Harlan‐Wistar rats (300-400 g) are injected NMDA
Dosage:	10 mg/kg
Administration:	I.p. twice daily for 4 days
Result:	Attenuated the attention deficit effectively. Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Harlan‐Wistar rats (300-400 g) are injected NMDA
Dosage:	10 mg/kg
Administration:	I.p. twice daily for 4 days
Result:	Attenuated the attention deficit effectively. Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (139.33 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7866 mL	13.9330 mL	27.8660 mL
5 mM	0.5573 mL	2.7866 mL	5.5732 mL
10 mM	0.2787 mL	1.3933 mL	2.7866 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献