CP-868388 free base|cas:702681-67-2|西域试剂

CP-868388 free base,99.84%

产品编号：Bellancom-116699| CAS NO：702681-67-2| 分子式：C₂₆H₃₃NO₅| 分子量：439.54

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货号	价格	库存与货期
Bellancom-116699	￥1500.00	杭州北京（现货）
Bellancom-116699	￥2400.00	杭州北京（现货）
Bellancom-116699	￥4900.00	杭州北京（现货）
Bellancom-116699	￥7900.00	杭州北京（现货）
Bellancom-116699	￥12500.00	杭州北京（现货）

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CP-868388 free base

产品介绍

CP-868388 free base 是一种有效的，选择性的，具有口服活性的 PPARα 激动剂，K_i 值为 10.8 nM。CP-868388 free base 对 PPARβ (K_i 为 3.47 μM) 和 PPARγ 几乎没有亲和力，具有降血脂和抗炎作用。

生物活性

CP-868388 free base is a potent, selective and orally active PPARα agonist with a K_i value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (K_i of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions.

体外研究

CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC₅₀ of 4.7 nM) and PGC-1α peptide.
CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC₅₀ of 18 nM in HepG2 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CP-868388 (0-3 mg/kg; oral gavage; once daily; for 2 days; male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male B6/CBF1J mice
Dosage:	0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Oral gavage; once daily; for 2 days
Result:	Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male B6/CBF1J mice
Dosage:	0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Oral gavage; once daily; for 2 days
Result:	Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (284.39 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2751 mL	11.3755 mL	22.7511 mL
5 mM	0.4550 mL	2.2751 mL	4.5502 mL
10 mM	0.2275 mL	1.1376 mL	2.2751 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式