Cyclic ADP-ribose cADPR|cas:119340-53-3|西域试剂

Cyclic ADP-ribose cADPR,96.0%

产品编号：Bellancom-N7395| CAS NO：119340-53-3| 分子式：C₁₅H₂₁N₅O₁₃P₂| 分子量：541.30

Cyclic ADP-ribose (cADPR) 是一种有效的钙动员 (calcium mobilization) 第二信使，是通过 ADP-核糖基环化酶从 NAD+ 合成的。Cyclic ADP-ribose 主要通过 Ryanodine 受体介导的内质网释放以及通过 TRPM2 通道开放引起的细胞外流入来增加胞质钙。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-N7395		￥10500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Cyclic ADP-ribose cADPR

产品介绍

Cyclic ADP-ribose (cADPR) 是一种有效的钙动员 (calcium mobilization) 第二信使，是通过 ADP-核糖基环化酶从 NAD⁺ 合成的。Cyclic ADP-ribose 主要通过 Ryanodine 受体介导的内质网释放以及通过 TRPM2 通道开放引起的细胞外流入来增加胞质钙。

生物活性

Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.

体外研究

cADPR (20 nM) elicits a large rapid Ca²⁺ release in sea urchin eggs homogenates.
cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes^[4].
cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 5 mg/mL (9.24 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8474 mL	9.2370 mL	18.4740 mL
5 mM	0.3695 mL	1.8474 mL	3.6948 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months。-80°C 储存时，请在 6 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-80°C

参考文献

. Galione A, et, al. Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science. 1991 Sep 6;253(5024):1143-6. [Content Brief]

. Lee HC, et, al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. J Biol Chem. 1989 Jan 25;264(3):1608-15. [Content Brief]

. Ribeiro JM, et al. Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase. Sci Rep. 2018 Jan 18;8(1):1036. [Content Brief]

[4]. Verderio C, et, al. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. J Neurochem. 2001 Aug;78(3):646-57. [Content Brief]

[5]. Zhong J, et, al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Front Neurosci. 2016 Jul 22;10:304. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

相关产品

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport