Muscimol 蝇蕈醇; Agarin; Agarine,98.0%

产品编号:Bellancom-N2313| CAS NO:2763-96-4| 分子式:C4H6N2O2| 分子量:114.10

毒蕈碱(Agarin)是一种精神活性异恶唑,是一种选择性神经递质GABA激动剂。毒蕈碱在高亲和力和低亲和力位点(Kd分别为10和270 nM)结合GABAA,以200 nM的EC50值刺激氯离子流出。毒蕈碱通过血脑屏障(BBB)并具有破坏记忆的作用。

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货号 包装 价格 库存与货期 购买量 操作
Bellancom-N2313
3400.00 杭州 北京(现货)
Bellancom-N2313
6000.00 杭州 北京(现货)

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Muscimol 蝇蕈醇; Agarin; Agarine

产品介绍 Muscimol (Agarin) 是一种精神活性异恶唑,是一种选择性神经递质 GABA 激动剂。Muscimol 在高亲和力和低亲和力位点结合 GABAA (Kd 分别为 10 和 270 nM),刺激氯化物流出,EC50 值为 200 nM。Muscimol 可以透过血脑屏障 (BBB),具有破坏记忆的作用。
生物活性

Muscimol (Agarin), a psychoactive isoxazole, is a selective neurotransmitter GABA agonist. Muscimol Binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Muscimol passes the blood-brain barrier (BBB) and has memory-disrupting effects.

体外研究
体内研究
体内研究
性状Solid
溶解性数据
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

相关文档

化学品安全说明书(MSDS)

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质检证书(COA)

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符号 GHS06
GHS06
信号词 Danger
危害声明 H300
警示性声明 P264-P301 + P310
个人防护装备 Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲) T: Toxic;
风险声明 (欧洲) 25
安全声明 (欧洲) S22;S45;S36/S37/S39
危险品运输编码 UN 1544 6.1/PG 2
WGK德国 3
RTECS号 NY3345000
包装等级 II
危险类别 6.1(a)
海关编码 2934999090
Name: Muscimol hydrate 98+% Material Safety Data Sheet
Synonym: 5-(Aminomethyl)-3-Isoxazolol; 5-Aminomethyl-3-Hydroxyisoxazole
CAS: 2763-96-4
Section 1 - Chemical Product MSDS Name:Muscimol hydrate 98+% Material Safety Data Sheet
Synonym:5-(Aminomethyl)-3-Isoxazolol; 5-Aminomethyl-3-Hydroxyisoxazole

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
2763-96-4 Muscimol 98+% 220-430-4
Hazard Symbols: T
Risk Phrases: 23/24/25

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed.The toxicological properties of this material have not been fully investigated.Highly toxic.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May be fatal if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 2763-96-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 150 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C4H6N2O2.xH2O
Molecular Weight: 114.10

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Acid chlorides, acid anhydrides, strong acids, strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 2763-96-4: NY3325000 LD50/LC50:
CAS# 2763-96-4: Oral, mouse: LD50 = 22 mg/kg; Oral, rat: LD50 = 45 mg/kg.
Carcinogenicity:
Muscimol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 2763-96-4: 1000 lb final RQ; 454 kg final RQ

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
Safety Phrases:
S 23 Do not inhale gas/fumes/vapour/spray.
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 2763-96-4: 3
Canada
CAS# 2763-96-4 is listed on Canada's NDSL List.
CAS# 2763-96-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 2763-96-4 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

~65%

2763-96-4结构式

2763-96-4

文献:McCarry; Savard Tetrahedron Letters, 1981 , vol. 22, # 51 p. 5153 - 5156

~33%

2763-96-4结构式

2763-96-4

文献:Konda; Takahashi; Onda Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1083 - 1087

~60%

2763-96-4结构式

2763-96-4

文献:Pevarello; Varasi Synthetic Communications, 1992 , vol. 22, # 13 p. 1939 - 1948

~38%

2763-96-4结构式

2763-96-4

文献:Oster, Timothy A.; Harris, Thomas M. Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4307 - 4311

~62%

2763-96-4结构式

2763-96-4

文献:Chiarino, D.; Napoletano, M.; Sala, A. Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3181 - 3182

~51%

2763-96-4结构式

2763-96-4

文献:Jaeger; Frey 1982 , vol. No. 4, p. 817 - 820

~%

2763-96-4结构式

2763-96-4

文献:Welch, W. M. Synthetic Communications, 1982 , vol. 12, # 14 p. 1089 - 1091

~%

2763-96-4结构式

2763-96-4

文献:Nakamura, Norio; Tajima, Yawara; Sakai, Kiyoshi Heterocycles, 1982 , vol. 17, p. 235 - 245

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