Sigma-1 receptor antagonist 1|cas:1639220-19-1|西域试剂

Sigma-1 receptor antagonist 1,99.76%

产品编号：Bellancom-125821| CAS NO：1639220-19-1| 分子式：C₁₉H₂₃Cl₂N₃O| 分子量：380.31

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货号	价格	库存与货期
Bellancom-125821	￥3000.00	杭州北京（现货）
Bellancom-125821	￥4800.00	杭州北京（现货）
Bellancom-125821	￥9200.00	杭州北京（现货）
Bellancom-125821	￥14500.00	杭州北京（现货）

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Sigma-1 receptor antagonist 1

产品介绍

Sigma?1 receptor antagonist 1 (compound 137) 是一种高效选择性的 sigma-1 受体 (σ1R) 拮抗剂，对 σ1R 具有高亲和力 (K_i = 1.06 nM)。Sigma?1 receptor antagonist 1 具有抗神经痛活性，有作为研究神经性疼痛活性分子的前景。

生物活性

Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (K_i = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain.

体外研究

Sigma‑1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (K_i = 1.06 nM) and good σ-1/2 selectivity (1344-fold).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Sigma‑1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Sigma‑1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 6.25 mg/mL (16.43 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6294 mL	13.1472 mL	26.2943 mL
5 mM	0.5259 mL	2.6294 mL	5.2589 mL
10 mM	0.2629 mL	1.3147 mL	2.6294 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式