E4CPG (RS-ECPG)|cas:170846-89-6|西域试剂

E4CPG (RS-ECPG),98.0%

产品编号：Bellancom-100372| CAS NO：170846-89-6| 分子式：C₁₁H₁₃NO₄| 分子量：223.23

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-100372	￥750.00	杭州北京（现货）
Bellancom-100372	￥1000.00	杭州北京（现货）
Bellancom-100372	￥2200.00	杭州北京（现货）
Bellancom-100372	￥3900.00	杭州北京（现货）
Bellancom-100372	￥7000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

E4CPG (RS-ECPG)

产品介绍

E4CPG ((RS)-ECPG) 是一种 Group I/Group II 代谢型谷氨酸受体 (Group I/Group II metabotropic glutamate receptor) 的拮抗剂。E4CPG 可以抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。

生物活性

E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.

体外研究

E4CPG acts at rat cortical mGluR with the K_B value of 0.367 mM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) ^[4].
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss mice (25-35 g)^[4]
Dosage:	3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.)
Administration:	Single injection
Result:	The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).

Animal Model:	Male Sprague-Dawley rats^[5]
Dosage:	35 nM/3.5 μL
Administration:	Single injection, i.c.v.
Result:	Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss mice (25-35 g)^[4]
Dosage:	3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.)
Administration:	Single injection
Result:	The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).

Animal Model:	Male Sprague-Dawley rats^[5]
Dosage:	35 nM/3.5 μL
Administration:	Single injection, i.c.v.
Result:	Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).

性状

Solid

溶解性数据

In Vitro:

DMSO : 10 mg/mL (44.80 mM; ultrasonic and adjust pH to 12 with NaOH)

H₂O : 1 mg/mL (4.48 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.4797 mL	22.3984 mL	44.7968 mL
5 mM	0.8959 mL	4.4797 mL	8.9594 mL
10 mM	0.4480 mL	2.2398 mL	4.4797 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式