NCX 470|cas:1194396-71-8|西域试剂

NCX 470,98.34%

产品编号：Bellancom-139419| CAS NO：1194396-71-8| 分子式：C₃₁H₄₆N₂O₈| 分子量：574.71

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货号	价格	库存与货期
Bellancom-139419	￥3500.00	杭州北京（现货）
Bellancom-139419	￥6000.00	杭州北京（现货）
Bellancom-139419	￥12500.00	杭州北京（现货）

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NCX 470

产品介绍

NCX 470 是第二代 NO 供体前列腺素类似物。NCX 470 有效降低高眼压和青光眼动物模型的眼压，通过激活双前列素介导的葡萄膜流出和 NO 介导的常规流出。NCX 470 可用于研究血管性高血压和青光眼的研究。

生物活性

NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. NCX 470 can be used for the research of cular hypertension and glaucoma.

体外研究

体内研究

NCX 470 shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension.
NCX 470 (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits.
NCX 470 (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) at 18 hours post dosing.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injection
Dosage:	0.14%
Administration:	Instillation; 0.14% 30 μL; once
Result:	Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injection
Dosage:	0.14%
Administration:	Instillation; 0.14% 30 μL; once
Result:	Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.

性状

Oil

溶解性数据

In Vitro:

DMSO : 100 mg/mL (174.00 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7400 mL	8.7000 mL	17.4001 mL
5 mM	0.3480 mL	1.7400 mL	3.4800 mL
10 mM	0.1740 mL	0.8700 mL	1.7400 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献