Diclofensine hydrochloride Ro 8-4650 hydrochloride|cas:34041-84-4|西域试剂

Diclofensine hydrochloride Ro 8-4650 hydrochloride,99.88%

产品编号：Bellancom-18610| CAS NO：34041-84-4| 分子式：C₁₇H₁₈Cl₃NO| 分子量：358.69

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货号	价格	库存与货期
Bellancom-18610	￥550.00	杭州北京（现货）
Bellancom-18610	￥920.00	杭州北京（现货）
Bellancom-18610	￥3900.00	杭州北京（现货）

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Diclofensine hydrochloride Ro 8-4650 hydrochloride

产品介绍

Diclofensine hydrochloride (Ro-8-4650 hydrochloride) 是高效单胺再摄取抑制剂，大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。

生物活性

Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. IC50 value: Target: Dopamine reuptake inhibitor The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake . Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM). On the other hand, diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release .

体外研究

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 52 mg/mL (144.97 mM)

DMSO : 6.67 mg/mL (18.60 mM; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7879 mL	13.9396 mL	27.8792 mL
5 mM	0.5576 mL	2.7879 mL	5.5758 mL
10 mM	0.2788 mL	1.3940 mL	2.7879 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 0.67 mg/mL (1.87 mM); Clear solution

此方案可获得 ≥ 0.67 mg/mL (1.87 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 6.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。