Raxatrigine GSK-1014802; CNV1014802|cas:934240-30-9|西域试剂

Raxatrigine GSK-1014802; CNV1014802,99.47%

产品编号：Bellancom-12796| CAS NO：934240-30-9| 分子式：C₁₈H₁₉FN₂O₂| 分子量：314.35

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-12796		￥1500.00	杭州北京（现货）
Bellancom-12796		￥2500.00	杭州北京（现货）

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Raxatrigine GSK-1014802; CNV1014802

产品介绍

Raxatrigine (GSK-1014802) 是钠离子通道Nav1.7有效抑制剂。

生物活性

Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

体外研究

Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. Raxatrigine (GSK-1014802) received orphan-drug designation from the US Food and Drug Administration in July 2013.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 83 mg/mL (264.04 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1812 mL	15.9058 mL	31.8117 mL
5 mM	0.6362 mL	3.1812 mL	6.3623 mL
10 mM	0.3181 mL	1.5906 mL	3.1812 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式