Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.

Half-maximal effective concentrations (EC₅₀) for mobilization of [Ca²⁺]_i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively.
Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC₅₀ of 6.7 nM, the binding of [^125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K_d = 0.33 nM).
Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [^125II] Y10-NPS, [^125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC₅₀ = 0.42 nM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97.  [Content Brief]