VQW-765 AQW-051|cas:669770-29-0|西域试剂

VQW-765 AQW-051,99.34%

产品编号：Bellancom-19490| CAS NO：669770-29-0| 分子式：C₁₉H₂₂N₂O| 分子量：294.39

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货号	价格	库存与货期
Bellancom-19490	￥1000.00	杭州北京（现货）
Bellancom-19490	￥1700.00	杭州北京（现货）
Bellancom-19490	￥3500.00	杭州北京（现货）
Bellancom-19490	￥5500.00	杭州北京（现货）
Bellancom-19490	￥9500.00	杭州北京（现货）

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VQW-765 AQW-051

产品介绍

VQW-765 (AQW-051) 是一种选择性的、具有口服活性的 alpha-7 烟碱乙酰胆碱受体 (α7-nAChR) 激动剂，对重组表达的人 α7-nAChR 的 pK_D 值为 7.56。VQW-765 在体内表现出抗焦虑作用。VQW-765 可用于焦虑障碍和急性焦虑的研究。

生物活性

VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pK_D value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety.

体外研究

VQW-765 对重组表达的人 α7-nACh 受体的 pK_D 值为 7.56。
VQW-765 在 GH3-ha7-22 细胞中重组表达的人 α7-nACh 受体刺激后，显示出对钙瞬态的强大激动活性，pEC₅₀ 值为 7.41。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

VQW-765 (0.03 和 0.3 mg/kg；口服，一次) 增加小鼠的认知和学习、记忆表现。
VQW-765 (1 mg/kg；口服，一次) 显示出抗焦虑作用，增加大鼠的社会探索时间，持续时间至少6小时。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	OF1/IC strain adult mice
Dosage:	0.03 and 0.3 mg/kg
Administration:	Oral administration; 0.03 and 0.3 mg/kg once
Result:	Increased the learning/memory performance with more time to scrutinize the novel partner than the familiar partner during the re-test trial at 24 h. Showed cognitive-enhancing effects in mice by the object recognition test (ORT).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	OF1/IC strain adult mice
Dosage:	0.03 and 0.3 mg/kg
Administration:	Oral administration; 0.03 and 0.3 mg/kg once
Result:	Increased the learning/memory performance with more time to scrutinize the novel partner than the familiar partner during the re-test trial at 24 h. Showed cognitive-enhancing effects in mice by the object recognition test (ORT).