PQM130|cas:2089415-51-8|西域试剂

PQM130,99.17%

产品编号：Bellancom-128346| CAS NO：2089415-51-8| 分子式：C₂₃H₂₇NO₄| 分子量：381.46

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货号	价格	库存与货期
Bellancom-128346	￥500.00	杭州北京（现货）
Bellancom-128346	￥800.00	杭州北京（现货）
Bellancom-128346	￥1600.00	杭州北京（现货）
Bellancom-128346	￥2600.00	杭州北京（现货）
Bellancom-128346	￥4200.00	杭州北京（现货）

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PQM130

产品介绍

PQM130是一种能透过大脑的、魏罗酮-多奈哌齐杂化化合物，是多靶点的候选活性分子，可用于Aβ_1-42 低聚物引起的神经毒性，还具有抗炎活性。PQM130 是具有神经保护作用的、有潜力的抗 AD 活性分子。

生物活性

PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget agent candidate against the neurotoxicity induced by Aβ_1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD agent development.

体外研究

体内研究

PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) .
Dosage:	0.5 and 1.0 mg/kg.
Administration:	IP injection daily for 10 days.
Result:	Ameliorated Aβ_1-42O-induced cognitive deficits in mice. Prevented Aβ_1-42O-induced neuronal death in mice. Antagonized Aβ_1-42O-Induced Oxidative Stress in Mice. Regulated GSK3β and ERK1/2 protein expressions in mice. Reduced Aβ_1-42O-induced astrocytic activation in mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) .
Dosage:	0.5 and 1.0 mg/kg.
Administration:	IP injection daily for 10 days.
Result:	Ameliorated Aβ_1-42O-induced cognitive deficits in mice. Prevented Aβ_1-42O-induced neuronal death in mice. Antagonized Aβ_1-42O-Induced Oxidative Stress in Mice. Regulated GSK3β and ERK1/2 protein expressions in mice. Reduced Aβ_1-42O-induced astrocytic activation in mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 1.82 mg/mL (4.77 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6215 mL	13.1075 mL	26.2151 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献