TPP-1|cas:2426685-25-6|西域试剂

TPP-1,99.19%

产品编号：Bellancom-P3139| CAS NO：2426685-25-6| 分子式：C₁₀₇H₁₅₀N₃₄O₃₂S₂| 分子量：2488.67

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P3139	￥600.00	杭州北京（现货）
Bellancom-P3139	￥1800.00	杭州北京（现货）
Bellancom-P3139	￥3000.00	杭州北京（现货）
Bellancom-P3139	￥6000.00	杭州北京（现货）

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TPP-1

产品介绍

TPP-1 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (K_D=95 nM)。动物模型中，TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。

生物活性

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function.

体外研究

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The K_D value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1.
TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5 to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector
Dosage:	4 mg/kg
Administration:	Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result:	Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5 to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector
Dosage:	4 mg/kg
Administration:	Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result:	Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (20.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.4018 mL	2.0091 mL	4.0182 mL
5 mM	0.0804 mL	0.4018 mL	0.8036 mL
10 mM	0.0402 mL	0.2009 mL	0.4018 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture