D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride|cas:2673-72-5|西域试剂

D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride

产品编号：Bellancom-W089922| CAS NO：2673-72-5| 分子式：C₁₈H₃₈ClNO₂| 分子量：335.95

D-红-鞘氨醇（红鞘氨醇）盐酸盐是一种特异性TRPM3激活剂。D-红-鞘氨醇还诱导视网膜母细胞瘤蛋白去磷酸化。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-W089922		￥1100.00	杭州北京（现货）
Bellancom-W089922		￥1800.00	杭州北京（现货）

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D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride

产品介绍

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride 是一种特异性 TRPM3 活化剂。D-erythro-Sphingosine 还诱导视网膜母细胞瘤蛋白 (retinoblastoma protein) 去磷酸化。

生物活性

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation.

体外研究

Extracellular application of D-erythro-Sphingosine (20 μM) induces an increase in [Ca²⁺]_i in TRPM3-transfected HEK293 cells within 20 to 30 s after start of application, whereas nontransfected control cells (NT) shows only very small responses.
D-erythro-Sphingosine (10 μM) induces currents through TRPM3.
Induction of retinoblastoma protein dephosphorylation by D-erythro-Sphingosine (500 nM; 24 h) precede inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Grimm C, et al. Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. Mol Pharmacol. 2005 Mar;67(3):798-805. [Content Brief]

. Chao R, et al. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25;267(33):23459-62. [Content Brief]

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D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride

D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride

化学品安全说明书(MSDS)

质检证书(COA)

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