TB5|cas:948841-07-4|西域试剂

TB5,95.0%

产品编号：Bellancom-100975| CAS NO：948841-07-4| 分子式：C₁₅H₁₄BrNOS| 分子量：336.25

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货号	价格	库存与货期
Bellancom-100975	￥500.00	杭州北京（现货）
Bellancom-100975	￥800.00	杭州北京（现货）
Bellancom-100975	￥2400.00	杭州北京（现货）
Bellancom-100975	￥3800.00	杭州北京（现货）

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TB5

产品介绍

TB5 是具有有效性，选择性和可逆性的 hMAO-B 抑制剂，K_i 值为 0.11±0.01 μM。

生物活性

TB5 is a potent, selective and reversible inhibitor of hMAO-B with a K_i value of 0.11±0.01 μM.

体外研究

TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with K_i and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 14.29 mg/mL (42.50 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9740 mL	14.8699 mL	29.7398 mL
5 mM	0.5948 mL	2.9740 mL	5.9480 mL
10 mM	0.2974 mL	1.4870 mL	2.9740 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式