Quipazine dimaleate|cas:150323-78-7|西域试剂

Quipazine dimaleate,99.87%

产品编号：Bellancom-101046| CAS NO：150323-78-7| 分子式：C₂₁H₂₃N₃O₈| 分子量：445.42

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货号	价格	库存与货期
Bellancom-101046	￥660.00	杭州北京（现货）
Bellancom-101046	￥1060.00	杭州北京（现货）
Bellancom-101046	￥1700.00	杭州北京（现货）

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Quipazine dimaleate

产品介绍

Quipazine dimaleate 是 5-HT 的激动剂，取代大鼠内皮层中 5-HT3R 的 [3H]GR65630 的 K_i 值为 1.4 nM。Quipazine dimaleate 对 SARS-CoV-2 具有抗病毒活性，EC₅₀ 值为 31.64 μM。Quipazine dimaleate 在外周模型中表现为 5-HT3R 的拮抗剂，可用于神经疾病研究。

生物活性

Quipazine dimaleate is a 5-HT agonist with a K_i value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC₅₀ of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research^[4].

体外研究

Quipazine dimaleate 对 5-HT1 和 5-HT2 具有结合效能，K_i 值均为 230 nM。
Quipazine dimaleate 取代大鼠内皮层中 5-HT3R 的 [3H]GR65630，K_i 值为 1.4 nM。
Quipazine dimaleate 对大鼠迷走神经具有拮抗作用，对 5-HT2，5-HT1 以及抑制 5-HT 释放的 pIC₅₀ 值分别为 6.1，6.49 和 6.17^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Quipazine dimaleate (2.5，5 和 7.5 mg/kg，每个剂量各一次；腹腔注射) 影响雄性和雌性大鼠对不同宏量营养素饮食的膳食自我选择。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female Wistar rats feed with different sources of the three macronutrients (Group 1: casein, corn starch, safflower oil. Group 2: egg protein, corn starch/sucrose, lard. Group S: casein hydrolysate, maltose dextrin, butter.)
Dosage:	2.5, 5 and 7.5 mg/kg
Administration:	Intraperitoneal injection; 2.5, 5 and 7.5 mg/kg, one dose for once
Result:	Increased water intake and food intake of male rats from Group S, and reduced food intake of female rats from Group 1 and Group 2s at 2h post-injection. Reduced food intake in female rats from Group 2, reduced protein intake in female rats from Group 1.

体内研究

Quipazine dimaleate (2.5，5 和 7.5 mg/kg，每个剂量各一次；腹腔注射) 影响雄性和雌性大鼠对不同宏量营养素饮食的膳食自我选择。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female Wistar rats feed with different sources of the three macronutrients (Group 1: casein, corn starch, safflower oil. Group 2: egg protein, corn starch/sucrose, lard. Group S: casein hydrolysate, maltose dextrin, butter.)
Dosage:	2.5, 5 and 7.5 mg/kg
Administration:	Intraperitoneal injection; 2.5, 5 and 7.5 mg/kg, one dose for once
Result:	Increased water intake and food intake of male rats from Group S, and reduced food intake of female rats from Group 1 and Group 2s at 2h post-injection. Reduced food intake in female rats from Group 2, reduced protein intake in female rats from Group 1.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (561.27 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2451 mL	11.2254 mL	22.4507 mL
5 mM	0.4490 mL	2.2451 mL	4.4901 mL
10 mM	0.2245 mL	1.1225 mL	2.2451 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.67 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明