ABT-100|cas:450839-40-4|西域试剂

ABT-100,98.18%

产品编号：Bellancom-119257| CAS NO：450839-40-4| 分子式：C₂₇H₁₉F₃N₄O₃| 分子量：504.46

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-119257		￥4000.00	杭州北京（现货）

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ABT-100

产品介绍

ABT-100 是一种有效的，高选择性和口服活性的 farnesyltransferase 抑制剂。ABT-100 抑制细胞增殖 (对于 EJ-1，DLD-1，MDA-MB-231，HCT-116，MiaPaCa-2，PC-3 和 DU-145 细胞的 IC₅₀ 分别为 2.2 nM，3.8 nM，5.9 nM，6.9 nM，9.2 nM，70 nM 和 818 nM)，可增加细胞凋亡并减少血管生成。ABT-100 具有广谱抗肿瘤活性。

生物活性

ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC₅₀s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity.

体外研究

ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. Also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells
Concentration:	0.1-100 nM
Incubation Time:	7 days
Result:	Demonstrated dose-dependent growth inhibition of human cancer cell lines.

体内研究
(In Vivo)

ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C.B-17 scid male mice with EJ-1 cells
Dosage:	6.25 mg/kg/day, 12.5 mg/kg/day
Administration:	Subcutaneous injection; daily; for 21 days
Result:	Regressed EJ-1 tumors in C.B-17 scid male mice.

体内研究

ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C.B-17 scid male mice with EJ-1 cells
Dosage:	6.25 mg/kg/day, 12.5 mg/kg/day
Administration:	Subcutaneous injection; daily; for 21 days
Result:	Regressed EJ-1 tumors in C.B-17 scid male mice.

体内研究

ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C.B-17 scid male mice with EJ-1 cells
Dosage:	6.25 mg/kg/day, 12.5 mg/kg/day
Administration:	Subcutaneous injection; daily; for 21 days
Result:	Regressed EJ-1 tumors in C.B-17 scid male mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (99.12 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9823 mL	9.9116 mL	19.8232 mL
5 mM	0.3965 mL	1.9823 mL	3.9646 mL
10 mM	0.1982 mL	0.9912 mL	1.9823 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献