Valproic acid sodium 丙戊酸钠; Sodium Valproate sodium|cas:1069-66-5|西域试剂

Valproic acid sodium 丙戊酸钠; Sodium Valproate sodium,98.14%

产品编号：Bellancom-10585A| CAS NO：1069-66-5| 分子式：C₈H₁₅NaO₂| 分子量：166.19

Valproic acid sodium salt是一种用于治疗癫痫，双相情感障碍和偏头痛的抗惊厥药。 Valproic acid抑制组蛋白脱乙酰基酶1 (HDAC1) 的 IC50 为 0.4 mM。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-10585A	￥350.00	杭州北京（现货）
Bellancom-10585A	￥450.00	杭州北京（现货）
Bellancom-10585A	￥800.00	杭州北京（现货）
Bellancom-10585A	￥1000.00	杭州北京（现货）

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Valproic acid sodium 丙戊酸钠; Sodium Valproate sodium

产品介绍

Valproic acid (Sodium Valproate) sodium 是一种具有口服活性的 HDAC 抑制剂，IC₅₀ 值为 0.5-2 mM，抑制 HDAC1 的活性，(IC₅₀，400 μM)，同时可诱导 HDAC2 的降解。Valproic acid sodium 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid sodium 可用于癫痫、双相情感障碍、代谢疾病、HIV 感染和偏头痛等的研究。

生物活性

Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches^[4]^[5]^[6]^[7].

体外研究

Valproic acid (VPA) (0-15 mM; 24 and 72 h) inhibits Hela cell growth in a dose- and time- dependent manner.
Valproic acid (10 mM; 24 h) significantly attenuates the activities of total, cytosol and nuclear HDACs.
Valproic acid (0-15 mM; 24 h) induces a G1 phase arrest at 1–3 mM and a G2/M phase arrest at 10 mM, and increases the percentage of sub-G1 cells in HeLa cells. Valproic acid also induces necrosis, apoptosis and lactate dehydrogenase (LDH) release.
Valproic acid (0-20 mM; 24 h) activates Tcf/Lef-dependent transcription and synergizes with lithium.
Valproic acid (0-5 mM; 0-18 h) increases β-catenin levels in Neuro2A cells.
Valproic acid (0-2 mM; 0-24 h) stimulates phosphorylation of AMPK and ACC in hepatocytes^[5].
Valproic acid (0-10 mM; 2 days) induces Notch1 signaling and morphologic differentiation, suppresses production of NE tumor markers in SCLC cells^[6].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HeLa cells
Concentration:	0, 1, 3, 5, 10 and 15 mM
Incubation Time:	24 and 72 h
Result:	HeLa cell growth was dose- and time-dependently decreased with an IC₅₀ of ~10 and 4 mM at 24 and 72 h.

Western Blot Analysis^[5]

Cell Line:	HeLa cells, Neuro2A cells or primary mouse hepatocytes
Concentration:	10 mM (HeLa); 0, 2, and 5 mM (Neuro2A); 0.2, 0.4, 0.8, 1.2 and 2 mM (hepatocytes)
Incubation Time:	24 h (HeLa); 0-18 h (Neuro2A); 0-24 h (hepatocytes)
Result:	Increased the form of acetylated histone 3. Reduced PARP, induced cleavage PARP, and downregulated Bcl-2. Increased β-catenin levels. Increased the phosphorylation of AMPK and ACC.

Cell Cycle Analysis

Cell Line:	HeLa cells
Concentration:	0, 1, 3, 5, 10 and 15 mM
Incubation Time:	24 h
Result:	Induced a G1 phase arrest at 1–3 mM, significantly induced a G2/M phase arrest at 10 mM, and increased the percentage of sub-G1 cells in HeLa cells in a dose-dependent manner at 24 h.

体内研究
(In Vivo)

Valproic acid (VPA) (500 mg/kg; i.p.; daily for 12 days) inhibits tumor angiogenesis in mice transplanted with Kasumi-1 cells.
Valproic acid (350 mg/kg; i.p.; once) enhances social behavior in rats^[4].
Valproic acid (0.26% (w/v); p.o. via drinking water; 14 days) decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice without hepatotoxicity^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice, Kasumi-1 tumor model
Dosage:	500 mg/kg
Administration:	Intraperitoneal injection, daily for 12 days
Result:	Inhibited tumor growth and tumor angiogenesis. Inhibited the mRNA and protein expression of VEGF, VEGFR2 and bFGF. Inhibited HDAC activity and increased acetylation of histone H3. Enhanced the accumulation of hyperacetylated histone H3 on VEGF promoters.

Animal Model:	Timed-pregnant Long Evans rats^[4]
Dosage:	350 mg/kg
Administration:	Intraperitoneal injection, once
Result:	Demonstrated more social investigation and play fighting than control animals.

Animal Model:	Obese phenotype of ob/ob mice^[5]
Dosage:	0.26% (w/v)
Administration:	Oral via drinking water, 14 days
Result:	Revealed a marked reduction in the accumulation of fats in the liver as compared with the untreated mice, significantly decreased liver mass to body mass, decreased serum triglyceride concentrations, and did not induce hepatotoxicity.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice, Kasumi-1 tumor model
Dosage:	500 mg/kg
Administration:	Intraperitoneal injection, daily for 12 days
Result:	Inhibited tumor growth and tumor angiogenesis. Inhibited the mRNA and protein expression of VEGF, VEGFR2 and bFGF. Inhibited HDAC activity and increased acetylation of histone H3. Enhanced the accumulation of hyperacetylated histone H3 on VEGF promoters.

Animal Model:	Timed-pregnant Long Evans rats^[4]
Dosage:	350 mg/kg
Administration:	Intraperitoneal injection, once
Result:	Demonstrated more social investigation and play fighting than control animals.

Animal Model:	Obese phenotype of ob/ob mice^[5]
Dosage:	0.26% (w/v)
Administration:	Oral via drinking water, 14 days
Result:	Revealed a marked reduction in the accumulation of fats in the liver as compared with the untreated mice, significantly decreased liver mass to body mass, decreased serum triglyceride concentrations, and did not induce hepatotoxicity.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice, Kasumi-1 tumor model
Dosage:	500 mg/kg
Administration:	Intraperitoneal injection, daily for 12 days
Result:	Inhibited tumor growth and tumor angiogenesis. Inhibited the mRNA and protein expression of VEGF, VEGFR2 and bFGF. Inhibited HDAC activity and increased acetylation of histone H3. Enhanced the accumulation of hyperacetylated histone H3 on VEGF promoters.

Animal Model:	Timed-pregnant Long Evans rats^[4]
Dosage:	350 mg/kg
Administration:	Intraperitoneal injection, once
Result:	Demonstrated more social investigation and play fighting than control animals.

Animal Model:	Obese phenotype of ob/ob mice^[5]
Dosage:	0.26% (w/v)
Administration:	Oral via drinking water, 14 days
Result:	Revealed a marked reduction in the accumulation of fats in the liver as compared with the untreated mice, significantly decreased liver mass to body mass, decreased serum triglyceride concentrations, and did not induce hepatotoxicity.

性状

Solid

溶解性数据

In Vitro:

H₂O : 125 mg/mL (752.15 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.0172 mL	30.0860 mL	60.1721 mL
5 mM	1.2034 mL	6.0172 mL	12.0344 mL
10 mM	0.6017 mL	3.0086 mL	6.0172 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (601.72 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [Content Brief]

. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. [Content Brief]

. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. [Content Brief]

[4]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [Content Brief]

[5]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [Content Brief]

[6]. Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148(1):31-7. [Content Brief]

[7]. Routy JP, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med. 2012 May;13(5):291-6. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	T:Toxic
风险声明 (欧洲)	R22;R36/38;R61
安全声明 (欧洲)	S36/37-S53-S45-S37/39-S26
危险品运输编码	2811
WGK德国	3
RTECS号	YV7876000
包装等级	III
危险类别	6.1(b)
海关编码	2915900090

1. 物质的识别

产品名：	Valproic acid sodium salt
CAS号：	1069-66-5
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Valproic acid sodium salt
别名：	Sodium valproate
分子式：	C8H15NaO2
分子量：	166.19

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

99-66-1

~99%

1069-66-5

文献：SCI PHARMTECH, INC. Patent: US2011/40122 A1, 2011 ; Location in patent: Page/Page column 2 ;

上游产品 1
99-66-1
下游产品 1
99-66-1

[1]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005.

[2]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.

[3]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50.

[4]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10.

[5]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41.

Valproic acid sodium 丙戊酸钠; Sodium Valproate sodium,98.14%

Valproic acid sodium 丙戊酸钠; Sodium Valproate sodium

化学品安全说明书(MSDS)

质检证书(COA)

1. 物质的识别

2. 合成/成分数据

3. 急救措施

4. 消防措施

5. 泄漏应急处理

6. 处理和储存

7. 接触控制和个人防护

8. 稳定性和反应活性

9. 毒性资料

10. 生态资料

11. 废弃处置

12. 运输信息

13. 法规信息

14. 其他信息

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