5-HT3 antagonist 5|cas:901599-43-7|西域试剂

5-HT3 antagonist 5,99.75%

产品编号：Bellancom-148038| CAS NO：901599-43-7| 分子式：C₁₆H₁₃N₃O₂| 分子量：279.29

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货号	价格	库存与货期
Bellancom-148038	￥1300.00	杭州北京（现货）
Bellancom-148038	￥2000.00	杭州北京（现货）
Bellancom-148038	￥4000.00	杭州北京（现货）
Bellancom-148038	￥6000.00	杭州北京（现货）

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5-HT3 antagonist 5

产品介绍

5-HT3 antagonist 5 是一种喹喔啉 -2- 甲酰胺化合物，是 5-HT₃ 受体拮抗剂。5-HT3 antagonist 5 对 5-HT₃ 激动剂和 2- 甲基 -5-HT 也具有拮抗作用，并在小鼠中表现出抗抑郁效果。

生物活性

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT₃ receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT₃ agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.

体外研究

5-HT3 antagonist 5 (compound 4c) exhibits 5-HT₃ receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT₃ agonist, 2-methyl-5-HT, with pA₂ value of 5.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice (23 ± 2 g)
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration
Result:	Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.

体内研究

5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice (23 ± 2 g)
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration
Result:	Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.

性状

Solid

溶解性数据

In Vitro:

DMSO : 20.83 mg/mL (74.58 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5805 mL	17.9025 mL	35.8051 mL
5 mM	0.7161 mL	3.5805 mL	7.1610 mL
10 mM	0.3581 mL	1.7903 mL	3.5805 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式