hCAI/II-IN-6|cas:694466-00-7|西域试剂

hCAI/II-IN-6,98.0%

产品编号：Bellancom-148135| CAS NO：694466-00-7| 分子式：C₁₉H₂₄N₄O₃S| 分子量：388.48

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货号	价格	库存与货期
Bellancom-148135	￥680.00	杭州北京（现货）
Bellancom-148135	￥1080.00	杭州北京（现货）
Bellancom-148135	￥2240.00	杭州北京（现货）
Bellancom-148135	￥3600.00	杭州北京（现货）
Bellancom-148135	￥5760.00	杭州北京（现货）

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hCAI/II-IN-6

产品介绍

hCAI/II-IN-6 是一种具有口服活性的 human carbonic anhydrase (CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII，对 hCA I，hCA II，hCA VII 和 hCA XII 的 K_i 值分别为 220，4.9，6.5 和＞50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。

生物活性

hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with K_i values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy.

体外研究

hCAI/II-IN-6 (0-50 μM) inhibits hCA I, hCA II , hCA VII and hCA XII activities with K_i values of 220, 4.9, 6.5 and ＞50000 nM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

hCAI/II-IN-6 (30-100mg/kg; i.p. once) shows good anticonvulsant effect in vivo.
hCAI/II-IN-6 (30 mg/kg; p.o. once) shows anti-MES activity in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice
Dosage:	30 and 100 mg/kg
Administration:	Intraperitoneal injection; 30-100 mg/kg once
Result:	Provided seizure attenuation and good anticonvulsant effect, and showed an ED₅₀ of 13.7mg/kg in anticonvulsant quantification study.

Animal Model:	Wistar albino rats
Dosage:	30 mg/kg
Administration:	Oral gavage; 30 mg/kg once
Result:	Showed anti-MES activity and significant protection from seizures up to 1h of drug administration and action was gone reduced after 1h.

体内研究

hCAI/II-IN-6 (30-100mg/kg; i.p. once) shows good anticonvulsant effect in vivo.
hCAI/II-IN-6 (30 mg/kg; p.o. once) shows anti-MES activity in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice
Dosage:	30 and 100 mg/kg
Administration:	Intraperitoneal injection; 30-100 mg/kg once
Result:	Provided seizure attenuation and good anticonvulsant effect, and showed an ED₅₀ of 13.7mg/kg in anticonvulsant quantification study.

Animal Model:	Wistar albino rats
Dosage:	30 mg/kg
Administration:	Oral gavage; 30 mg/kg once
Result:	Showed anti-MES activity and significant protection from seizures up to 1h of drug administration and action was gone reduced after 1h.