SKF 83822|cas:74115-08-5|西域试剂

SKF 83822

产品编号：Bellancom-116874| CAS NO：74115-08-5| 分子式：C₂₀H₂₂ClNO₂| 分子量：343.85

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Bellancom-116874	￥3800.00	杭州北京（现货）
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SKF 83822

产品介绍

SKF 83822 是一种非典型的多巴胺 D1 受体激动剂。SKF 83822 激活腺苷酸环化酶，但不激活 PLC。SKF 83822 也被证明可以通过 cAMP 的产生来刺激 AC。SKF 83822 可用于精神分裂症的研究。

生物活性

SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase, but not PLC. SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia.

体外研究

体内研究

SKF 83822（25-100 μg/kg；皮下注射；在使用拮抗剂后单次给药）以剂量依赖的方式在大鼠体内产生强烈的旋转反应。SKF 83822 还刺激去神经纹状体中 IEG 产物 c-Fos、Fra2、Zif/268 和 Arc 的强烈表达。
SKF 83822 在猴子中分别以 0.25 mg/kg 和 0.35 mg/kg 的中等和高剂量显示出显著效果。并且 SKF 83822（0.15-0.35 mg/kg；皮下注射；单剂量）诱导运动而不诱导运动障碍。SKF 83822 导致极度兴奋和运动激活的状态，没有刻板印象。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult, male Sprague-Dawley derived rats
Dosage:	6.25 μg/kg, 25 μg/kg, 50 μg/kg, and 100 μg/kg; with or without 0.5 mg/kg antagonist SCH 23390.
Administration:	SC; single dose, 30 min after antagonist treatment.
Result:	Produced a strong rotational response at 50 μg/kg which was approximately midway between that produced by the 25 and 100 μg/kg doses in the first experiment. Could be inhibited by antagonist of dopamine D1 receptor, SCH 23390.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult, male Sprague-Dawley derived rats
Dosage:	6.25 μg/kg, 25 μg/kg, 50 μg/kg, and 100 μg/kg; with or without 0.5 mg/kg antagonist SCH 23390.
Administration:	SC; single dose, 30 min after antagonist treatment.
Result:	Produced a strong rotational response at 50 μg/kg which was approximately midway between that produced by the 25 and 100 μg/kg doses in the first experiment. Could be inhibited by antagonist of dopamine D1 receptor, SCH 23390.