IWP L6 Porcn Inhibitor III|cas:1427782-89-5|西域试剂

IWP L6 Porcn Inhibitor III,99.02%

产品编号：Bellancom-15825| CAS NO：1427782-89-5| 分子式：C₂₅H₂₀N₄O₂S₂| 分子量：472.58

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-15825	￥850.00	杭州北京（现货）
Bellancom-15825	￥3000.00	杭州北京（现货）
Bellancom-15825	￥5400.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

IWP L6 Porcn Inhibitor III

产品介绍

IWP L6 (Porcn Inhibitor III) 是高活性 Porcn 抑制剂，EC₅₀ 为 0.5 nM。

生物活性

IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC₅₀ of 0.5 nM.

体外研究

IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 1.43 mg/mL (3.03 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1160 mL	10.5802 mL	21.1604 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式