Rovanersen WVE-120101|cas:2072901-32-5|西域试剂

Rovanersen WVE-120101,94.24%

产品编号：Bellancom-132593| CAS NO：2072901-32-5| 分子量：6617.00

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-132593		￥7400.00	杭州北京（现货）
Bellancom-132593		￥11700.00	杭州北京（现货）

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Rovanersen WVE-120101

产品介绍

Rovanersen (WVE-120101) 是一种反义寡核苷酸，通过特异靶向 huntingtin (HTT) 基因的突变mRNA拷贝，而不影响正常的 HTT基因的mRNA，从而防止有缺陷的 huntingtin 蛋白的产生。Rovanersen 可用于亨廷顿病的研究。

生物活性

Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can be used for huntington’s disease research.

体外研究

In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 50 mg/mL (7.56 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.1511 mL	0.7556 mL	1.5113 mL
5 mM	0.0302 mL	0.1511 mL	0.3023 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献