UPGL00004|cas:1890169-95-5|西域试剂

UPGL00004,98.0%

产品编号：Bellancom-119377| CAS NO：1890169-95-5| 分子式：C₂₅H₂₆N₈O₂S₂| 分子量：534.66

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货号	价格	库存与货期
Bellancom-119377	￥900.00	杭州北京（现货）
Bellancom-119377	￥1600.00	杭州北京（现货）
Bellancom-119377	￥3200.00	杭州北京（现货）
Bellancom-119377	￥5500.00	杭州北京（现货）
Bellancom-119377	￥9500.00	杭州北京（现货）

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UPGL00004

产品介绍

UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂 (IC₅₀=29 nM; K_d=27 nM)。UPGL00004 强烈抑制高度侵袭性三阴性乳腺癌细胞系的增殖。

生物活性

UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC₅₀=29 nM; K_d=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines.

体外研究

UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC₅₀s of 70, 129, and 262 nM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (233.79 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8703 mL	9.3517 mL	18.7035 mL
5 mM	0.3741 mL	1.8703 mL	3.7407 mL
10 mM	0.1870 mL	0.9352 mL	1.8703 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式