ASP2535|cas:374886-51-8|西域试剂

ASP2535,99.70%

产品编号：Bellancom-110176| CAS NO：374886-51-8| 分子式：C₂₂H₁₈N₆O| 分子量：382.42

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-110176		￥7100.00	杭州北京（现货）
Bellancom-110176		￥12000.00	杭州北京（现货）

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ASP2535

产品介绍

ASP-2535 是一种高效、有口服活性、选择性的，脑渗透性和中心活性的 GlyT1 抑制剂。ASP-2535 能改善精神分裂症和阿尔茨海默病动物模型的认知障碍。

生物活性

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease.

体外研究

ASP2535 potently inhibits rat GlyT1 (IC₅₀=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice.
ASP2535 (1-3 mg/kg, p.o.) also improves the PCP-induced deficit in prepulse inhibition in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-week-old male ddY mice
Dosage:	0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Oral administration
Result:	Significantly attenuated the MK-801-induced decrease in alternation rate.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-week-old male ddY mice
Dosage:	0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Oral administration
Result:	Significantly attenuated the MK-801-induced decrease in alternation rate.