Teclistamab|cas:2119595-80-9|西域试剂

Teclistamab,99.71%

产品编号：Bellancom-P99392| CAS NO：2119595-80-9

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-P99392		￥8500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Teclistamab

产品介绍

Teclistamab 是一种人源化的 BCMA 和 CD3 双特异性抗体，可识别靶细胞上的 BCMA 和 T 细胞上的 CD3，诱导 T 细胞介导的细胞毒性，导致 T 细胞的活化和随后的靶细胞裂解。Teclistamab 可用于多发性骨髓瘤等相关疾病研究。

生物活性

Teclistamab is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM).

体外研究

Teclistamab (0.01-1000 nM, 48 h) 可以诱导 T 细胞介导的细胞毒性，在 H929 细胞中的 EC₅₀ 值为 0.15 nM，在MM.1R 细胞系中为 0.06 nM，在 RPMI 8226 细胞系中为 0.45 nM。
Teclistamab (0.01-1000 nM, 48 h) 能以剂量依赖方式结合 CD138 ⁺人 BM 单核细胞，并诱导人 BM 单核细胞的细胞毒性。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Teclistamab (i.v., 0.1-1 μg, once every 2 days) 在雌性 NSG（NOD/SCID/γc^-/）小鼠 H929 细胞模型中具有大剂量的抗肿瘤活性。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female NSG mice infected with H929 cell lines
Dosage:	0.1 µg (0.005 mg/kg), 0.5 µg (0.025 mg/kg), or 1 µg (0.05 mg/kg)
Administration:	i.v., on days 0, 3, 5, 7, and 10
Result:	Completely inhibited tumor growth at doses of 0.5 and 1 μg, while no inhibition of tumor growth was observed at a dose of 0.1 μg.

体内研究

Teclistamab (i.v., 0.1-1 μg, once every 2 days) 在雌性 NSG（NOD/SCID/γc^-/）小鼠 H929 细胞模型中具有大剂量的抗肿瘤活性。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female NSG mice infected with H929 cell lines
Dosage:	0.1 µg (0.005 mg/kg), 0.5 µg (0.025 mg/kg), or 1 µg (0.05 mg/kg)
Administration:	i.v., on days 0, 3, 5, 7, and 10
Result:	Completely inhibited tumor growth at doses of 0.5 and 1 μg, while no inhibition of tumor growth was observed at a dose of 0.1 μg.