Exendin (5-39),99.81%

产品编号:Bellancom-P2497| CAS NO:196109-27-0| 分子式:C169H262N44O54S| 分子量:3806.30

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货号 包装 价格 库存与货期 购买量 操作
Bellancom-P2497
2600.00 杭州 北京(现货)
Bellancom-P2497
5800.00 杭州 北京(现货)
Bellancom-P2497
9500.00 杭州 北京(现货)

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Exendin (5-39)

产品介绍 Exendin (5-39) 是一种强效的胰高血糖素样肽 1 (GLP-1 receptor) 受体拮抗剂。Exendin (5-39) 改善 β-淀粉样蛋白沉积的大鼠的记忆障碍。
生物活性

Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.

体外研究
体内研究

Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (3 weeks old and 18 days pregnant)
Dosage: 0.3 μg
Administration: Intracerebroventricular injection; 0.3 μg; once daily; 1-week
Result: Inhibited GLT-1 protein levels and inhibited long-term depression in rats.
体内研究

Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (3 weeks old and 18 days pregnant)
Dosage: 0.3 μg
Administration: Intracerebroventricular injection; 0.3 μg; once daily; 1-week
Result: Inhibited GLT-1 protein levels and inhibited long-term depression in rats.
性状Solid
溶解性数据
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

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