Enpp-1-IN-14|cas:2687222-59-7|西域试剂

Enpp-1-IN-14,99.87%

产品编号：Bellancom-147389| CAS NO：2687222-59-7| 分子式：C₁₅H₂₂ClN₅O₄S| 分子量：403.88

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货号	价格	库存与货期
Bellancom-147389	￥1500.00	杭州北京（现货）
Bellancom-147389	￥2500.00	杭州北京（现货）
Bellancom-147389	￥5500.00	杭州北京（现货）
Bellancom-147389	￥8500.00	杭州北京（现货）
Bellancom-147389	￥13500.00	杭州北京（现货）

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Enpp-1-IN-14

产品介绍

Enpp-1-IN-14 (Compound 015) 是一种有效的外核苷酸焦磷酸酶/磷酸二酯酶 (ENPP1) 抑制剂，对重组人 ENPP-1 的 IC₅₀ 为 32.38 nM。Enpp-1-IN-14 具有抗肿瘤活性。

生物活性

Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC₅₀ value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity.

体外研究

体内研究

Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×10⁵ MC38 cells)
Dosage:	50 mg/kg
Administration:	IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)
Result:	Significantly inhibited tumor growth.

体内研究

Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×10⁵ MC38 cells)
Dosage:	50 mg/kg
Administration:	IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)
Result:	Significantly inhibited tumor growth.

性状

Solid

溶解性数据

In Vitro:

DMSO : 9.62 mg/mL (23.82 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4760 mL	12.3799 mL	24.7598 mL
5 mM	0.4952 mL	2.4760 mL	4.9520 mL
10 mM	0.2476 mL	1.2380 mL	2.4760 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式