RN-1 dihydrochloride|cas:1781835-13-9|西域试剂

RN-1 dihydrochloride,99.75%

产品编号：Bellancom-110130| CAS NO：1781835-13-9| 分子式：C₂₃H₃₁Cl₂N₃O₂| 分子量：452.42

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货号	价格	库存与货期
Bellancom-110130	￥1400.00	杭州北京（现货）
Bellancom-110130	￥2400.00	杭州北京（现货）
Bellancom-110130	￥8900.00	杭州北京（现货）
Bellancom-110130	￥14500.00	杭州北京（现货）

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RN-1 dihydrochloride

产品介绍

RN-1 dihydrochloride 是一种有效的、可透过血脑屏障、不可逆的、选择性的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，IC₅₀ 为 70 nM。RN-1 dihydrochloride 对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC₅₀ 值分别为 0.51 μM 和 2.785 μM。

生物活性

RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC₅₀ values of 0.51 μM and 2.785 μM respectively.

体外研究

RN-1 dihydrochloride shows cytotoxic for ovarian cancer cells (SKOV3, OVCAR3, A2780 and cisplatin-resistant A2780cis), with IC50 values of ≈100-200 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

RN-1 (3-10 mg/kg; i.p.; daily; for 2 or 4 consecutive weeks) dihydrochloride effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology in SCD mice.
In C57BL/6 male mice, after intraperitoneal administration of RN-1 dihydrochloride (10 mg/kg), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. The brain/plasma exposure ratio is 88.9. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sickle cell disease (SCD) mice
Dosage:	3 mg/kg or 10 mg/kg
Administration:	i.p.; daily; for 2 or 4 consecutive weeks
Result:	Effectively induced HbF levels in red blood cells and reduced disease pathology in SCD mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sickle cell disease (SCD) mice
Dosage:	3 mg/kg or 10 mg/kg
Administration:	i.p.; daily; for 2 or 4 consecutive weeks
Result:	Effectively induced HbF levels in red blood cells and reduced disease pathology in SCD mice.

性状

Solid

溶解性数据

In Vitro:

H₂O : 20 mg/mL (44.21 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2103 mL	11.0517 mL	22.1034 mL
5 mM	0.4421 mL	2.2103 mL	4.4207 mL
10 mM	0.2210 mL	1.1052 mL	2.2103 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶