TC LPA5 4|cas:1393814-38-4|西域试剂

TC LPA5 4,99.22%

产品编号：Bellancom-107615| CAS NO：1393814-38-4| 分子式：C₂₃H₂₃ClN₂O₃| 分子量：410.89

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货号	价格	库存与货期
Bellancom-107615	￥1600.00	杭州北京（现货）
Bellancom-107615	￥2500.00	杭州北京（现货）
Bellancom-107615	￥5500.00	杭州北京（现货）
Bellancom-107615	￥9500.00	杭州北京（现货）

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TC LPA5 4

产品介绍

TC LPA5 4 是一种特异性非脂质 LPA₅ (GPR92) 拮抗剂。TC LPA5 4 抑制 LPA 诱导的离体人血小板 (LPA5-RH7777细胞系) 聚集，IC₅₀ 为 800 nM。TC LPA5 4 对 LPA₅ 的选择性超过 80 个其他筛选活性分子靶点。TC LPA5 4 抑制甲状腺癌细胞的增殖和迁移。

生物活性

TC LPA5 4 is a LPA₅ (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA₅-RH7777 cell line) with an IC₅₀ of 800 nM. TC LPA5 4 displays selectivity for LPA₅ over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.

体外研究

TC LPA5 4 inhibits the proliferation on thyroid cancer cells CGTH-W3, TPC-1, B-CAPAP, and BHT101 significantly with IC₅₀ at 103.0 μM, 84.9 μM, 55.9μM, and 57.17 μM. TC LPA5 4 (5 μM; 24 hours) significantly inhibits LPA-stimulated migration of CGTH-W3 and TPC-1 cells, with an inhibitory rate of ~ 30%. B-CPAP and BHT101 cells expressed higher LPAR5 mRNA. TC LPA5 4 inhibits these two cell lines’ proliferations with IC₅₀ at 55.9μM and 57.17 μM. CGTH-W3 and TPC-1 cells expressed lower LPAR5 mRNA. TC LPA5 4 displays differential antitumor activity with IC₅₀ at 103.0 μM and 84.9 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

TC LPA5 4 (10 mg/kg; intraperitoneal injection; 5 days/week for 2 weeks) could delay CGTH-W3 xenograft growth in nude mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts)
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 5 days/week for 2 weeks
Result:	Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.

体内研究

TC LPA5 4 (10 mg/kg; intraperitoneal injection; 5 days/week for 2 weeks) could delay CGTH-W3 xenograft growth in nude mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts)
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 5 days/week for 2 weeks
Result:	Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.

性状

Solid

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (152.11 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4337 mL	12.1687 mL	24.3374 mL
5 mM	0.4867 mL	2.4337 mL	4.8675 mL
10 mM	0.2434 mL	1.2169 mL	2.4337 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献