AC1-IN-1|cas:2762422-55-7|西域试剂

AC1-IN-1,99.81%

产品编号：Bellancom-145830| CAS NO：2762422-55-7| 分子式：C₁₈H₁₈FN₅O₂| 分子量：355.37

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货号	价格	库存与货期
Bellancom-145830	￥4200.00	杭州北京（现货）
Bellancom-145830	￥6700.00	杭州北京（现货）
Bellancom-145830	￥12500.00	杭州北京（现货）

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AC1-IN-1

产品介绍

AC1-IN-1 是一种有效的选择性 AC1 抑制剂，其 IC₅₀ 为 0.54 µM. AC1-IN-1 在炎症性疼痛小鼠模型中表现出适度的抗异常疼痛的作用。AC1-IN-1 具有 CNS 活性。

生物活性

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC₅₀ of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.

体外研究

AC1-IN-1 (compound 38; HEK293 cells; 30 µM, 1 hours) shows nontoxic to this human cell line.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:	HEK293 cells
Concentration:	30 µM
Incubation Time:	1 hours
Result:	Showed nontoxic to HEK293 cells.

体内研究
(In Vivo)

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)
Dosage:	5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration:	Intravenous injection; 2 hours
Result:	Displayed modest, yet statistically significant, antiallodynic effects.

体内研究

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)
Dosage:	5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration:	Intravenous injection; 2 hours
Result:	Displayed modest, yet statistically significant, antiallodynic effects.

体内研究

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)
Dosage:	5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration:	Intravenous injection; 2 hours
Result:	Displayed modest, yet statistically significant, antiallodynic effects.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (70.35 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8140 mL	14.0698 mL	28.1397 mL
5 mM	0.5628 mL	2.8140 mL	5.6279 mL
10 mM	0.2814 mL	1.4070 mL	2.8140 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式