Muscimol hydrochloride Agarin hydrochloride; Agarine hydrochloride,95.0%
产品编号：Bellancom-N2313B| CAS NO：3579-03-1| 分子式：C4H7ClN2O2| 分子量：150.56
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Muscimol hydrochloride Agarin hydrochloride; Agarine hydrochloride
| 产品介绍 | Muscimol (Agarin; Agarine) hydrochloride 是一种具有精神活性的异恶唑。Muscimol hydrochloride 也是抑制性神经递质 GABA 离子型受体的选择性激动剂。Muscimol hydrochloride 可以从毒蝇伞和相关蘑菇中分离出来。总之，Muscimol 是一种有效的 GABAA 受体激动剂 (EC50=0.2 μM)，部分 GABAC 受体 激动剂和无活性的 GABAB 受体 激动剂。Muscimol hydrochloride 具有镇静、抗焦虑和致幻作用。 | ||||||||
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| 生物活性 | Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects. | ||||||||
| 体外研究 | |||||||||
| 体内研究 |
Muscimol 影响前额叶皮层的功能，并且在注射到腹侧前额叶皮层后（1μL，5μg/μL；前额叶皮层输注），损害猴子在计数任务中的表现，但在注射到背侧前额叶皮层后没有影响。 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究 |
Muscimol 影响前额叶皮层的功能，并且在注射到腹侧前额叶皮层后（1μL，5μg/μL；前额叶皮层输注），损害猴子在计数任务中的表现，但在注射到背侧前额叶皮层后没有影响。 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 性状 | Solid | ||||||||
| 溶解性数据 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||
| 参考文献 |
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