Z-Ile-Leu-aldehyde Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII|cas:161710-10-7|西域试剂

Z-Ile-Leu-aldehyde Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII

产品编号：Bellancom-12465| CAS NO：161710-10-7| 分子式：C₂₀H₃₀N₂O₄| 分子量：362.46

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货号	价格	库存与货期
Bellancom-12465	￥2333.00	杭州北京（现货）
Bellancom-12465	￥3500.00	杭州北京（现货）
Bellancom-12465	￥5000.00	杭州北京（现货）

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Z-Ile-Leu-aldehyde Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII

产品介绍

Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的 γ-secretase 和 notch 的肽醛抑制剂。

生物活性

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.

体外研究

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays.
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCRsup>

Cell Line:	CD4⁺ T cells from C57BL/6 mice.
Concentration:	25 μM.
Incubation Time:	24, 48, 72 hours.
Result:	DownregulateD RORt and IL-17 mRNA expression.

Cell Viability Assaysup>

Cell Line:	MOPC315.BM cells.
Concentration:	0, 12, 15 μM.
Incubation Time:	24-48 h hours.
Result:	Reduced viability and induced apoptosis in MOPC315.BM cells

体内研究
(In Vivo)

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MOPC315.BM mouse model.
Dosage:	10 mg/kg.
Administration:	Intraperitoneally either for 14 days.
Result:	Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice.

体内研究

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MOPC315.BM mouse model.
Dosage:	10 mg/kg.
Administration:	Intraperitoneally either for 14 days.
Result:	Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice.

体内研究

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MOPC315.BM mouse model.
Dosage:	10 mg/kg.
Administration:	Intraperitoneally either for 14 days.
Result:	Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 41 mg/mL (113.12 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7589 mL	13.7946 mL	27.5893 mL
5 mM	0.5518 mL	2.7589 mL	5.5179 mL
10 mM	0.2759 mL	1.3795 mL	2.7589 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式