5-HT4 antagonist 1 is a 5-HT₄ receptor antagonist with a pK_i of 9.6.

5-HT4 antagonist 1 (compound 6b) is a 5-HT₄ receptor antagonist with a pK_i of 9.6.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t_1/2 in other species, including the mouse (t_1/2 7 h), rat (t_1/2 12 h) and mini-pig (t_1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t_1/2 of >100 h.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t_1/2 in other species, including the mouse (t_1/2 7 h), rat (t_1/2 12 h) and mini-pig (t_1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t_1/2 of >100 h.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Clark RD, et al. Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1697-700.  [Content Brief]