CL 316243|cas:138908-40-4|西域试剂

CL 316243,98.31%

产品编号：Bellancom-116771A| CAS NO：138908-40-4| 分子式：C₂₀H₁₈ClNNa₂O₇| 分子量：465.79

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货号	价格	库存与货期
Bellancom-116771A	￥2500.00	杭州北京（现货）
Bellancom-116771A	￥4000.00	杭州北京（现货）
Bellancom-116771A	￥8000.00	杭州北京（现货）

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CL 316243

产品介绍

CL316243 是一种高效的选择性 β3-肾上腺素受体 (β3-adrenoceptor) 激动剂，EC₅₀ 为 3 nM，但其对 β1/2-受体选择性却比较差。CL316243 是一种有效的脂肪细胞脂解刺激剂，可增加棕色脂肪组织的生热作用和代谢率。CL316243 具有有潜力用于肥胖症，糖尿病和尿失禁的相关研究。

生物活性

CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC₅₀ of 3 nM, but is an extremely poor to β1/2- receptors.CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.

体外研究

CL 316243 displays binding affinities with IC₅₀ values of 0.6 μM and 1 μM for rat heart and rat soleus muscle respectively.
CL 316243 inhibits spontaneously contracting, isolated rat detrusor strips in a concentration dependent manner with a mean concentration inhibiting 50% of maximal response of 2.65 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 weeks) elevates the mRNA and protein expression levels of UCP1 in BAT, irrespective of diet.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks
Dosage:	0.1 mg/kg/day
Administration:	once a day; 1 weeks
Result:	Exhibited a premium effect of obesity in mice.

体内研究

CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 weeks) elevates the mRNA and protein expression levels of UCP1 in BAT, irrespective of diet.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks
Dosage:	0.1 mg/kg/day
Administration:	once a day; 1 weeks
Result:	Exhibited a premium effect of obesity in mice.

性状

Solid

溶解性数据

In Vitro:

H₂O : 20 mg/mL (42.94 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1469 mL	10.7345 mL	21.4689 mL
5 mM	0.4294 mL	2.1469 mL	4.2938 mL
10 mM	0.2147 mL	1.0734 mL	2.1469 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶