AH-7614|cas:6326-06-3|西域试剂

AH-7614,99.0%

产品编号：Bellancom-19996| CAS NO：6326-06-3| 分子式：C₂₀H₁₇NO₃S| 分子量：351.42

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-19996	￥700.00	杭州北京（现货）
Bellancom-19996	￥1200.00	杭州北京（现货）
Bellancom-19996	￥2500.00	杭州北京（现货）
Bellancom-19996	￥4000.00	杭州北京（现货）
Bellancom-19996	￥6000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

AH-7614

产品介绍

AH-7614 是一种有效和选择性的 FFA4 (GPR120) 拮抗剂，对人，小鼠和大鼠 FFA4 的 pIC₅₀ 值分别为 7.1，8.1 和 8.1。AH-7614 对 FFA4 的选择性高于 FFA1 (pIC₅₀<4.6)。AH-7614 能够阻断多不饱和 ω-6 脂肪酸亚油酸和 FFA4 激动剂的作用。

生物活性

AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC₅₀s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC₅₀<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist.

体外研究

AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca²⁺ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.
AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.
AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC₅₀=7.70).
AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

AH7614 (50 μg; intratumoral injection once every 4 d for 20 d) reduces the tumor growth in mice.
AH7614 (50 μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (284.56 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8456 mL	14.2280 mL	28.4560 mL
5 mM	0.5691 mL	2.8456 mL	5.6912 mL
10 mM	0.2846 mL	1.4228 mL	2.8456 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.11 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.11 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。