SKF-34288 hydrochloride 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride|cas:320386-54-7|西域试剂

SKF-34288 hydrochloride 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride,95.0%

产品编号：Bellancom-128923| CAS NO：320386-54-7| 分子式：C₆H₆ClNO₂S| 分子量：191.64

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货号	价格	库存与货期
Bellancom-128923	￥650.00	杭州北京（现货）
Bellancom-128923	￥1700.00	杭州北京（现货）
Bellancom-128923	￥3000.00	杭州北京（现货）

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SKF-34288 hydrochloride 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride

产品介绍

SKF-34288 hydrochloride 是一种具有口服活性的磷酸烯醇丙酮酸羧激酶 (PEPCK) 抑制剂 (K_i: 2-9 μM)。SKF-34288 hydrochloride 通过抑制葡萄糖合成产生降血糖作用。SKF-34288 hydrochloride 抑制 Asn 代谢并导致氨基酸和酰胺的增加。

生物活性

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (K_i: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides.

体外研究

SKF-34288 hydrochloride (0.01-1 mM, 48 h) 抑制 C2C12 细胞增殖^[4]。
SKF-34288 hydrochloride (0.25-1 mM，0-5 天) 诱导 C2C12 细胞的肌原性分化^[4]。
SKF-34288 hydrochloride (0.25 或 1 mM) 降低 Pck2 和丝氨酸生物合成相关基因的 mRNA 表达^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	C2C12 cell
Concentration:	0, 0.01, 0.1, 0.25, 0.5, 1 mM
Incubation Time:	48 h
Result:	Dose-dependently inhibited C2C12 cell proliferation.

体内研究
(In Vivo)

SKF-34288 hydrochloride (37.5-150mg/kg, 口服) 降低饥饿大鼠的血糖^[6]。
SKF-34288 hydrochloride (25 mg/kg，皮下注射) 中和沙丁胺醇介导的兔子高血糖症。
SKF-34288 hydrochloride (30 和 300 mg/kg，腹腔注射) 降低丙酮酸诱导的大鼠血糖水平^[5]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Starved rats^[6]
Dosage:	37.5, 75 and 150mg/kg
Administration:	Oral administration (p.o.)
Result:	Showed dose-dependent magnitude and duration of the hypoglycaemic effect.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Starved rats^[6]
Dosage:	37.5, 75 and 150mg/kg
Administration:	Oral administration (p.o.)
Result:	Showed dose-dependent magnitude and duration of the hypoglycaemic effect.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Starved rats^[6]
Dosage:	37.5, 75 and 150mg/kg
Administration:	Oral administration (p.o.)
Result:	Showed dose-dependent magnitude and duration of the hypoglycaemic effect.

性状

Solid

溶解性数据

In Vitro:

H₂O : 5 mg/mL (26.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.2181 mL	26.0906 mL	52.1812 mL
5 mM	1.0436 mL	5.2181 mL	10.4362 mL
10 mM	0.5218 mL	2.6091 mL	5.2181 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶