SID 3712249 MiR-544 Inhibitor 1|cas:522606-67-3|西域试剂

SID 3712249 MiR-544 Inhibitor 1,99.91%

产品编号：Bellancom-19731| CAS NO：522606-67-3| 分子式：C₁₇H₂₁N₇| 分子量：323.40

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货号	价格	库存与货期
Bellancom-19731	￥850.00	杭州北京（现货）
Bellancom-19731	￥1450.00	杭州北京（现货）
Bellancom-19731	￥3100.00	杭州北京（现货）
Bellancom-19731	￥4950.00	杭州北京（现货）
Bellancom-19731	￥7950.00	杭州北京（现货）

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SID 3712249 MiR-544 Inhibitor 1

产品介绍

SID 3712249 (MiR-544 Inhibitor 1) 是一种 miR-544 生物合成抑制剂。SID 3712249 直接与前体 miRNA 结合。SID 3712249 阻断成熟 microRNA 的产生并减少 miR-544、HIF-1α 和 ATM 转录物。SID 3712249 可用于癌症研究。

生物活性

SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer.

体外研究

SID 3712249 (compound 1, 20 nM, 48 h) disrupts miR-544-mediated inhibition of BMI1 based on significant increases in the RFP/BFP ratio.
SID 3712249 (20 nM, 48 h) inhibits precursor but not mature miR-544 binding to BMI1 or mTOR3’-UTR.
SID 3712249 (20 nM, 48 h) results in accumulation of pre-miR-544 and a decrease in miR-544 levels in MCF10A cells.
SID 3712249 (20 nM, 5 days) induces apoptosis in MDA-MB-231 and MCF- 7 cells and has no effect on cell survival in normoxic conditions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	MDA-MB-231, MCF-7 cells
Concentration:	20 nM
Incubation Time:	5 days
Result:	Induced apoptosis and has no effect on cell survival in normoxic conditions (flow cytometric analysis of Annexin V and PI stainning).

体内研究
(In Vivo)

SID 3712249 (compound 1, 100 μL of 40 μM, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model.
SID 3712249 (20 nM, pre-treated GFP-labeled MDA-MB-231 cells, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MDA-MB-231-GFP-luc tumor model
Dosage:	100 μL of 40 μM
Administration:	Intraperitoneal injection
Result:	Inhibited tumor growth (evidenced by live animal bioluminescent imaging) with no overt side effects. Decreased levels of miR-544, ATM, and HIF-1α and increased levels of mTOR (resected tumor samples).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MDA-MB-231-GFP-luc tumor model
Dosage:	100 μL of 40 μM
Administration:	Intraperitoneal injection
Result:	Inhibited tumor growth (evidenced by live animal bioluminescent imaging) with no overt side effects. Decreased levels of miR-544, ATM, and HIF-1α and increased levels of mTOR (resected tumor samples).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MDA-MB-231-GFP-luc tumor model
Dosage:	100 μL of 40 μM
Administration:	Intraperitoneal injection
Result:	Inhibited tumor growth (evidenced by live animal bioluminescent imaging) with no overt side effects. Decreased levels of miR-544, ATM, and HIF-1α and increased levels of mTOR (resected tumor samples).

性状

Solid

溶解性数据

In Vitro:

DMSO : 16.67 mg/mL (51.55 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0921 mL	15.4607 mL	30.9215 mL
5 mM	0.6184 mL	3.0921 mL	6.1843 mL
10 mM	0.3092 mL	1.5461 mL	3.0921 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式