S55746 hydrochloride BCL201 hydrochloride|cas:1448525-91-4|西域试剂

S55746 hydrochloride BCL201 hydrochloride,98.69%

产品编号：Bellancom-117288A| CAS NO：1448525-91-4| 分子式：C₄₃H₄₃ClN₄O₆| 分子量：747.28

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货号	价格	库存与货期
Bellancom-117288A	￥1250.00	杭州北京（现货）
Bellancom-117288A	￥2200.00	杭州北京（现货）
Bellancom-117288A	￥4500.00	杭州北京（现货）
Bellancom-117288A	￥8100.00	杭州北京（现货）
Bellancom-117288A	￥15000.00	杭州北京（现货）

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S55746 hydrochloride BCL201 hydrochloride

产品介绍

S55746 hydrochloride (BCL201 hydrochloride) 是一种有效、可口服、选择性的 BCL-2 抑制剂，其 K_i 值和 K_d 值分别为 1.3 nM 和 3.9 nM。S55746 hydrochloride (BCL201 hydrochloride) 具有抗肿瘤活性且毒性低。

生物活性

S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity.

体外研究

S55746 (0-1 μM) potently and selectively induces cell death.
S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	H146 and RS4;11 cell lines.
Concentration:	0, 0.1, 0.3 and 1 μM.
Incubation Time:	72 hours.
Result:	Potently induced RS4;11 cell killing after 72 h of treatment with an IC₅₀ of 71.6 nM.

体内研究
(In Vivo)

S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor .
S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4;11 and Toledo models time- and dose-dependently.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female SCID/beige mice implanted subcutaneously with 3×10⁶ Toledo or RS4;11.
Dosage:	20, 50, 100 mg/kg.
Administration:	Oral gavage daily for 7 consecutive days.
Result:	Induced significant anti-tumor activity time- and dose-dependently.

Animal Model:	SCID/beige female mice with RS4;11 tumor xenografts.
Dosage:	25 and 100 mg/kg.
Administration:	Single oral gavage treatment.
Result:	Did not induce platelet loss in vivo at 25 and 100 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female SCID/beige mice implanted subcutaneously with 3×10⁶ Toledo or RS4;11.
Dosage:	20, 50, 100 mg/kg.
Administration:	Oral gavage daily for 7 consecutive days.
Result:	Induced significant anti-tumor activity time- and dose-dependently.

Animal Model:	SCID/beige female mice with RS4;11 tumor xenografts.
Dosage:	25 and 100 mg/kg.
Administration:	Single oral gavage treatment.
Result:	Did not induce platelet loss in vivo at 25 and 100 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female SCID/beige mice implanted subcutaneously with 3×10⁶ Toledo or RS4;11.
Dosage:	20, 50, 100 mg/kg.
Administration:	Oral gavage daily for 7 consecutive days.
Result:	Induced significant anti-tumor activity time- and dose-dependently.

Animal Model:	SCID/beige female mice with RS4;11 tumor xenografts.
Dosage:	25 and 100 mg/kg.
Administration:	Single oral gavage treatment.
Result:	Did not induce platelet loss in vivo at 25 and 100 mg/kg.

性状

Solid

溶解性数据

In Vitro:

DMSO : 200 mg/mL (267.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3382 mL	6.6909 mL	13.3819 mL
5 mM	0.2676 mL	1.3382 mL	2.6764 mL
10 mM	0.1338 mL	0.6691 mL	1.3382 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 5 mg/mL (6.69 mM); Clear solution

此方案可获得 ≥ 5 mg/mL (6.69 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 5 mg/mL (6.69 mM); Clear solution

此方案可获得 ≥ 5 mg/mL (6.69 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。