Chicoric acid 菊苣酸; Cichoric acid; Dicaffeoyltartaric acid|cas:6537-80-0|西域试剂

Chicoric acid 菊苣酸; Cichoric acid; Dicaffeoyltartaric acid,99.95%

产品编号：Bellancom-N0457| CAS NO：6537-80-0| 分子式：C₂₂H₁₈O₁₂| 分子量：474.37

Chicoric acid (Cichoric acid) 是一种口服有效的二咖啡基酒石酸，可以诱导活性氧 (ROS) 的产生。Chicoric acid 抑制细胞活力，并通过 ROS 介导的 PI3K/Akt 和 MAPK 信号通路诱导 3T3-L1 前脂肪细胞中的线粒体依赖性细胞凋亡。Chicoric acid 增加葡萄糖摄取，改善胰岛素抵抗，并减轻氨基葡萄糖诱导的炎症。Chicoric acid 具有抗糖尿病和抗氧化、抗炎作用。

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货号	价格	库存与货期
Bellancom-N0457	￥600.00	杭州北京（现货）
Bellancom-N0457	￥1350.00	杭州北京（现货）
Bellancom-N0457	￥2400.00	杭州北京（现货）

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Chicoric acid 菊苣酸; Cichoric acid; Dicaffeoyltartaric acid

产品介绍

Chicoric acid (Cichoric acid) 是一种口服有效的二咖啡基酒石酸，可以诱导活性氧 (ROS) 的产生。Chicoric acid 抑制细胞活力，并通过 ROS 介导的 PI3K/Akt 和 MAPK 信号通路诱导 3T3-L1 前脂肪细胞中的线粒体依赖性细胞凋亡。Chicoric acid 增加葡萄糖摄取，改善胰岛素抵抗，并减轻氨基葡萄糖诱导的炎症。Chicoric acid 具有抗糖尿病和抗氧化、抗炎作用。

生物活性

Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects.

体外研究

Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, and 72 h) causes a dose- and time-dependent decrease in cell viability.
Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway.
Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt.
Chicoric acid (25, 50, 100 µM; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, and Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells.
Chicoric acid (100 µM; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells.
Chicoric acid (100 µM) has no effects on HepG2 cell viability.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	3T3-L1 preadipocytes
Concentration:	10-200 μM
Incubation Time:	24, 48, and 72 hours
Result:	Had no effect on the viability of 3T3-L1 preadipocytes with 10-50 μM for 24 h, but significantly decreased cell viability with 100 μM and 200 μM.

Apoptosis Analysis

Cell Line:	3T3-L1 preadipocytes
Concentration:	100 μM
Incubation Time:	48 hours
Result:	Demonstrated typical characteristics of apoptosis such as cell shrinkage, chromatin condensation, and the increased permeability of cell membranes after DAPI and AO/EB staining.

Western Blot Analysis

Cell Line:	3T3-L1 preadipocytes
Concentration:	100 μM
Incubation Time:	48 hours
Result:	Decreased the protein level of p-Akt in a dose- and time-dependent manner. The protein level of total Akt was not affected

体内研究
(In Vivo)

Chicoric acid (Cichoric acid; 60 mg/kg/day; drinking water for 4 weeks) inhibits pancreas apoptosis and adjusts islet function in diabetic mice, leading to an increase in insulin generation and secretion in C57BL/6J mice with Streptozotocin (STZ; 50 mg/kg; ip; for consecutive 5 days).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)
Dosage:	60 mg/kg
Administration:	Drinking water; daily; for 4 weeks
Result:	Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses. Showed a remarkable increase in body weight starting at week 7.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)
Dosage:	60 mg/kg
Administration:	Drinking water; daily; for 4 weeks
Result:	Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses. Showed a remarkable increase in body weight starting at week 7.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)
Dosage:	60 mg/kg
Administration:	Drinking water; daily; for 4 weeks
Result:	Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses. Showed a remarkable increase in body weight starting at week 7.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (210.81 mM; Need ultrasonic)

DMSO : 1 mg/mL (2.11 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1081 mL	10.5403 mL	21.0806 mL
5 mM	0.4216 mL	2.1081 mL	4.2161 mL
10 mM	0.2108 mL	1.0540 mL	2.1081 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (105.40 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Haifang Xiao, et al. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. J Agric Food Chem. 2013 Feb 20;61(7):1509-20. [Content Brief]

. Di Zhu, et al. Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells. J Agric Food Chem. 2015 Dec 30;63(51):10903-13. [Content Brief]

. Di Zhu, et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017 Sep;107(Pt A):138-149. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

符号	GHS07, GHS08
信号词	Danger
危害声明	H302-H317-H334
警示性声明	P261-P280-P284-P301 + P312 + P330-P304 + P340-P342 + P311
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲)	Xn
风险声明 (欧洲)	22-42/43
安全声明 (欧洲)	22-36/37-45
危险品运输编码	NONH for all modes of transport
海关编码	29182900

1. 物质的识别

产品名：	Cichoric-Acid
CAS号：	6537-80-0
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Cichoric-Acid
别名：	Cichoric acid; Dicaffeoyltartaric acid
分子式：	C22H18O12
分子量：	474.37

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。