Exendin-4 acetate 醋酸艾塞那肽; Exenatide acetate|cas:914454-01-6|西域试剂

Exendin-4 acetate 醋酸艾塞那肽; Exenatide acetate,99.43%

产品编号：Bellancom-13443A| CAS NO：914454-01-6| 分子式：C₁₈₆H₂₈₆N₅₀O₆₂S| 分子量：4246.62

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货号	价格	库存与货期
Bellancom-13443A	￥900.00	杭州北京（现货）
Bellancom-13443A	￥1960.00	杭州北京（现货）
Bellancom-13443A	￥2910.00	杭州北京（现货）
Bellancom-13443A	￥4100.00	杭州北京（现货）

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Exendin-4 acetate 醋酸艾塞那肽; Exenatide acetate

产品介绍

Exendin-4 acetate (Exenatide acetate) 是由39个氨基酸组成的多肽。它是长效的 glucagon-like peptide-1 受体激动剂，IC₅₀ 值为 3.22 nM。

生物活性

Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM.

体外研究

In human umbilical vein endothelial cells, Exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells with IC₅₀ of 5 μM at 48 hour.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Both low- and high-dose Exendin-4 treatment in ob/ob mice improve serum ALT and reduce serum glucose, and calculated HOMA scores compared with control. Exendin-4-treated ob/ob mice sustain a marked reduction in the net weight gain in the final 4 weeks of the study period^[4]. Animals treated with Exendin-4 have more pancreatic acinar inflammation, more pyknotic nuclei and weigh significantly less than control rats. Exendin-4 treatment is associated with lower leptin levels as well as lower HOMA values in rats^[5]. Exenatide causes dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H₂S but also by NO and CO^[6].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 66.66 mg/mL (15.70 mM)

H₂O : 25 mg/mL (5.89 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2355 mL	1.1774 mL	2.3548 mL
5 mM	0.0471 mL	0.2355 mL	0.4710 mL
10 mM	0.0235 mL	0.1177 mL	0.2355 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶