Diprotin A TFA Ile-Pro-Ile TFA|cas:209248-71-5|西域试剂

Diprotin A TFA Ile-Pro-Ile TFA,99.14%

产品编号：Bellancom-111174A| CAS NO：209248-71-5| 分子式：C₁₉H₃₂F₃N₃O₆| 分子量：455.47

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货号	价格	库存与货期
Bellancom-111174A	￥650.00	杭州北京（现货）
Bellancom-111174A	￥990.00	杭州北京（现货）
Bellancom-111174A	￥2100.00	杭州北京（现货）
Bellancom-111174A	￥2900.00	杭州北京（现货）

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Diprotin A TFA Ile-Pro-Ile TFA

产品介绍

Diprotin A TFA (Ile-Pro-Ile TFA) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。

生物活性

Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

体外研究

Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 77.5 mg/mL (170.15 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1955 mL	10.9777 mL	21.9553 mL
5 mM	0.4391 mL	2.1955 mL	4.3911 mL
10 mM	0.2196 mL	1.0978 mL	2.1955 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶