M-31850|cas:281224-40-6|西域试剂

M-31850,99.81%

产品编号：Bellancom-104050| CAS NO：281224-40-6| 分子式：C₂₈H₂₁N₃O₄| 分子量：463.48

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货号	价格	库存与货期
Bellancom-104050	￥500.00	杭州北京（现货）
Bellancom-104050	￥900.00	杭州北京（现货）
Bellancom-104050	￥1200.00	杭州北京（现货）
Bellancom-104050	￥2000.00	杭州北京（现货）

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M-31850

产品介绍

M-31850 是一种有效，选择性和竞争性的 β-己糖胺酶 (β-hexosaminidase (Hex)) 抑制剂，对人 HexA 和 HexB 的 IC₅₀ 分别为 6.0 µM 和 3.1 µM。M-31850 还以 K_i 为 2.5 μM 来竞争性抑制 β-N-acetyl-D-hexosaminidase OfHex2。

生物活性

M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC₅₀s of 6.0 µM and 3.1 µM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a K_i of 2.5 μM.

体外研究

M-31850 shows some activity towards Jack Bean Hex (JBHex) and bacterial Hex from Streptomyces plicatus (SpHex) (IC₅₀ of 280 µM and >500 µM for JBHex and SpHex, respectively).
M-31850 produces a dose dependent increase in MUG hydrolysis (Hex S levels) in lysates from treated infantile Sandhoff disease (ISD) cells.
M-31850 increases the half-life of the mutant Hex A from Adult forms of Tay-Sachs (ATSD) cells more than two-fold at 44° C, relative to the enzyme heated in the presence of DMSO. M-31850 acts as a classic competitive inhibitor of Hex (K_m increases and V_max is unaffected by increasing amounts of M-31850), with a K_i of 0.8 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (10.79 mM; ultrasonic and adjust pH to 6 with HCl)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1576 mL	10.7880 mL	21.5759 mL
5 mM	0.4315 mL	2.1576 mL	4.3152 mL
10 mM	0.2158 mL	1.0788 mL	2.1576 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献