TR antagonist 1|cas:500794-88-7|西域试剂

TR antagonist 1,98.89%

产品编号：Bellancom-111443| CAS NO：500794-88-7| 分子式：C₂₅H₂₃Br₂NO₄| 分子量：561.26

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货号	价格	库存与货期
Bellancom-111443	￥5500.00	杭州北京（现货）
Bellancom-111443	￥8500.00	杭州北京（现货）
Bellancom-111443	￥25500.00	杭州北京（现货）
Bellancom-111443	￥39500.00	杭州北京（现货）

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TR antagonist 1

产品介绍

TR antagonist 1是高亲和力的甲状腺激素受体 (thyroid hormone receptor (TR)) 拮抗剂，对 TRα 和 TRβ 的IC₅₀ 值分别为 36 和 22 nM。

生物活性

TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC₅₀s of 36 and 22 nM for TRα and TRβ, respectively.

体外研究

TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC₅₀=36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC₅₀ 32 nM for both TRAFα1 and TRAFβ1.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 83.3 mg/mL (148.42 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7817 mL	8.9085 mL	17.8171 mL
5 mM	0.3563 mL	1.7817 mL	3.5634 mL
10 mM	0.1782 mL	0.8909 mL	1.7817 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献