PF-06471553|cas:1808094-07-6|西域试剂

PF-06471553,98.18%

产品编号：Bellancom-108339| CAS NO：1808094-07-6| 分子式：C₂₃H₂₅N₅O₄S| 分子量：467.54

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货号	价格	库存与货期
Bellancom-108339	￥4800.00	杭州北京（现货）
Bellancom-108339	￥7400.00	杭州北京（现货）
Bellancom-108339	￥14000.00	杭州北京（现货）

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PF-06471553

产品介绍

PF-06471553 是一种有效的，选择性的，可口服的 monoacylglycerol acyltransferase 3 (MGAT3) 抑制剂，IC₅₀ 值为 92 nM。

生物活性

PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC₅₀ of 92 nM.

体外研究

PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC₅₀ of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC₅₀, >50 μM), DGAT2 (IC₅₀, >100 μM), MGAT1 (IC₅₀, 14.9 μM), and MGAT2 (IC₅₀, 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC₅₀ of 205 nM (pIC₅₀, 6.69).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 150 mg/mL (320.83 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1389 mL	10.6943 mL	21.3885 mL
5 mM	0.4278 mL	2.1389 mL	4.2777 mL
10 mM	0.2139 mL	1.0694 mL	2.1389 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式